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Masao Sasamata Selected Research

N- (6- methoxy- 5- (2- methoxyphenoxy)- 2- (pyrimidin- 2- yl)pyrimidin- 4- yl)- 2- phenylethenesulfonamide (YM598)

2/2008In vitro and in vivo effects of endothelin-1 and YM598, a selective endothelin ET A receptor antagonist, on the lower urinary tract.
6/2005A novel and selective endothelin ET(A) receptor antagonist YM598 prevents the development of chronic hypoxia-induced pulmonary hypertension in rats.
11/2004Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice.
11/2004Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist.
9/2004Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist.
8/2004The orally active nonpeptide selective endothelin ETA receptor antagonist YM598 prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.
5/2004Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain.
2/2004Effect of single oral administration of YM598, a novel selective endothelin ETA receptor antagonist, on blood pressure in normotensive and hypertensive rats.

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Masao Sasamata Research Topics

Disease

14Neoplasms (Cancer)
10/2012 - 05/2004
10Overactive Urinary Bladder (Overactive Bladder)
05/2012 - 05/2004
7Body Weight (Weight, Body)
03/2014 - 06/2004
5Urinary Bladder Neck Obstruction (Bladder Neck Obstruction)
01/2010 - 03/2006
4Hyperglycemia
03/2014 - 01/2012
4Cerebral Infarction
03/2013 - 04/2003
4Melanoma (Melanoma, Malignant)
08/2011 - 09/2004
4Prostatic Neoplasms (Prostate Cancer)
03/2011 - 05/2004
4Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
05/2009 - 07/2007
4Diarrhea
05/2009 - 07/2007
3Type 2 Diabetes Mellitus (MODY)
03/2014 - 01/2012
3Glucose Intolerance
09/2013 - 11/2009
3Non-Hodgkin Lymphoma (Lymphosarcoma)
10/2012 - 03/2011
3Hypoglycemia (Reactive Hypoglycemia)
04/2012 - 11/2009
3Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
01/2010 - 02/2008
3Hyponatremia
01/2009 - 01/2007
3Pain (Aches)
07/2008 - 05/2004
3Infarction (Infarctions)
02/2007 - 01/2003
2Inflammation (Inflammations)
07/2014 - 09/2013
2Metabolic Syndrome (Dysmetabolic Syndrome X)
09/2013 - 12/2006
2Insulin Resistance
09/2013 - 12/2006
2Breast Neoplasms (Breast Cancer)
09/2011 - 03/2011
2Neoplasm Metastasis (Metastasis)
09/2011 - 07/2008
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2011 - 03/2011
2Lymphoma (Lymphomas)
06/2011 - 01/2005
2Experimental Arthritis
01/2008 - 04/2005
2Arthritis (Polyarthritis)
01/2008 - 04/2005
2Urge Urinary Incontinence (Urge Incontinence)
05/2007 - 01/2007
2Embolic Stroke
01/2007 - 01/2003
2Lower Urinary Tract Symptoms
09/2006 - 08/2004
2Edema (Dropsy)
11/2005 - 11/2004
2Pulmonary Hypertension
06/2005 - 08/2004
2Hypoxia (Hypoxemia)
06/2005 - 08/2004
2Right Ventricular Hypertrophy
06/2005 - 08/2004
2Cancer Pain
11/2004 - 05/2004
2Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
11/2004 - 05/2004
2Hematoma
05/2003 - 04/2003
2Cerebral Hemorrhage
05/2003 - 04/2003
1Albuminuria
07/2014
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
07/2014
1Weight Loss (Weight Reduction)
03/2014
1Hyperlipidemias (Hyperlipidemia)
09/2013
1Hyperinsulinism (Hyperinsulinemia)
09/2013
1Obesity
09/2013
1Triple Negative Breast Neoplasms
09/2011

Drug/Important Bio-Agent (IBA)

10sepantroniumIBA
10/2012 - 09/2007
9SurvivinIBA
09/2012 - 09/2007
8Solifenacin SuccinateFDA Link
01/2010 - 05/2004
8N- (6- methoxy- 5- (2- methoxyphenoxy)- 2- (pyrimidin- 2- yl)pyrimidin- 4- yl)- 2- phenylethenesulfonamide (YM598)IBA
02/2008 - 02/2004
7Endothelins (Endothelin)IBA
02/2008 - 05/2004
6Tamsulosin (Flomax)FDA LinkGeneric
11/2010 - 08/2004
5ipragliflozinIBA
07/2014 - 01/2012
5Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
08/2009 - 05/2004
5Pharmaceutical PreparationsIBA
01/2009 - 04/2005
4Glucose (Dextrose)FDA LinkGeneric
09/2013 - 12/2006
4Muscarinic AntagonistsIBA
01/2010 - 05/2004
4ramosetron (Nasea)IBA
05/2009 - 07/2007
4SodiumIBA
01/2009 - 11/2005
3Streptozocin (Streptozotocin)FDA Link
07/2014 - 01/2012
3Sodium-Glucose Transport ProteinsIBA
07/2014 - 01/2012
3Insulin (Novolin)FDA Link
09/2013 - 12/2006
3ElectrolytesIBA
01/2009 - 01/2007
3Arginine Vasopressin (Argipressin)IBA
01/2009 - 01/2007
3conivaptan (Vaprisol)FDA Link
01/2009 - 01/2005
3Vasopressin Receptors (Arginine Vasopressin Receptor)IBA
01/2009 - 01/2005
3Celecoxib (Celebrex)FDA Link
01/2008 - 01/2005
3salicylhydroxamic acid (SHAM)IBA
02/2007 - 05/2004
3Bosentan (Tracleer)FDA Link
11/2004 - 08/2004
2Blood Glucose (Blood Sugar)IBA
09/2013 - 11/2009
2Niacinamide (Nicotinamide)FDA LinkGeneric
09/2013 - 01/2012
2Therapeutic UsesIBA
09/2013 - 08/2004
2mirabegronIBA
03/2013 - 05/2012
2Docetaxel (Taxotere)FDA Link
08/2011 - 06/2011
2Hormones (Hormone)IBA
03/2011 - 09/2007
2Analgesics (Analgesic Drugs)IBA
07/2008 - 01/2005
2Serotonin (5 Hydroxytryptamine)IBA
02/2008 - 11/2007
2Loperamide (Imodium)FDA LinkGeneric
02/2008 - 07/2007
2loxoprofen (CS 600)IBA
01/2008 - 11/2005
2Mineral Oil (Liquid Paraffin)FDA LinkGeneric
01/2008 - 04/2005
2Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
01/2008 - 04/2005
2darifenacinFDA Link
02/2007 - 05/2004
2Tolterodine Tartrate (Detrol)FDA Link
02/2007 - 05/2004
2Vasopressins (Vasopressin)IBA
01/2007 - 01/2005
2Endothelin-1 (Endothelin 1)IBA
06/2006 - 05/2004
2Dinoprostone (PGE2)FDA Link
11/2005 - 01/2005
2CarrageenanIBA
11/2005 - 01/2005
2AtrasentanIBA
11/2004 - 09/2004
2SaltsIBA
09/2004 - 05/2004
2Collagenases (Collagenase)FDA Link
05/2003 - 04/2003
2Heparin (Liquaemin)FDA LinkGeneric
05/2003 - 04/2003
2AMPA Receptors (AMPA Receptor)IBA
04/2003 - 01/2003
2YM 872IBA
04/2003 - 01/2003
1Rituximab (Mabthera)FDA Link
10/2012
1Hypoglycemic Agents (Hypoglycemics)IBA
04/2012
1Progesterone Receptors (Progesterone Receptor)IBA
09/2011
1Estrogens (Estrogen)FDA Link
09/2011

Therapy/Procedure

8Therapeutics
09/2011 - 01/2007
3Oral Administration
06/2005 - 07/2004
2Intravenous Administration
01/2007 - 01/2005
1Drug Therapy (Chemotherapy)
10/2012